Comparative Evaluation of Hepatoprotective Activities of Geniposide, Crocins and Crocetin by CCl4-Induced liver Injury in Mice
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Comparative Evaluation of Hepatoprotective Activities of Geniposide, Crocins and Crocetin by CCl4-Induced liver Injury in Mice
Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chromatographically. Then, mice were orally administrated with geniposide (400 mg/kg b.w.), crocins (400 mg/kg b.w.), crocin-1 (400 mg/kg b.w.) and crocetin (14...
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Background and objectives: Free radicals and other oxidants have important roles in liver cell toxicity. Some natural products are potent scavengers of oxidative agents. Crocus caspius is an endemic species of Caspian forest. Flowers of Crocus genus contain phenolic compound and carotenoid as antioxidant agent. This study investigated the antioxidant and hepat...
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BACKGROUND Micromeria croatica (Pers.) Schott is an aromatic plant from Lamiaceae family previously found to possess potent in vitro antioxidant activity which is mainly attributed to the high level of polyphenolic substances. The aim of this study was to investigate the hepatoprotective activity and possible underlying mechanisms of Micromeria croatica ethanolic extract (MC) using a model of c...
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ژورنال
عنوان ژورنال: Biomolecules & Therapeutics
سال: 2016
ISSN: 2005-4483,1976-9148
DOI: 10.4062/biomolther.2015.094